Recombinomics has stated that a paper published by the National Institute of Health has reported the presence of similar binding receptors in swine flu samples from Brazil, Ukraine and Norway.
Although WHO stated that this change was "not significant" in the Ukraine samples, it was associated with the fatal cases and is cause for concern. The concern was increased by the announcement from Norway indicating the same change was found in fatal H1N1 lung infections there also.
Some have commented that this change was spontaneous and diid not spread, although this change was found in all four deceased patients in Ukraine from two distinct locations -- meaning they did indeed spread. What is serious, though, is what this means for the spread of the pandemic.
The concept of acquisition via recombination has serious implications for the current pandemic. It was used to predict the D225G change, in part because the change was "in play" and appearing in July/August sequences at increasing frequency, even though the H1N1 sequences represented different genetic backgrounds. Similarly the clusters of Tamiflu resistance in Wales and North Carolina are also driven by recombination, as happened when the identical change was acquired in H1N1 seasonal flu in patients who were not taking Tamiflu (oseltamivir).
These changes to the swine flu virus are making it resistant to Tamiflu, the best medicine to fight this kind of viral infection.
Similarly the clusters of Tamiflu resistance in Wales and North Carolina are also driven by recombination, as happened when the identical change was acquired in H1N1 seasonal flu in patients who were not taking Tamiflu (oseltamivir).
Although WHO stated that this change was "not significant" in the Ukraine samples, it was associated with the fatal cases and is cause for concern. The concern was increased by the announcement from Norway indicating the same change was found in fatal H1N1 lung infections there also.
Some have commented that this change was spontaneous and diid not spread, although this change was found in all four deceased patients in Ukraine from two distinct locations -- meaning they did indeed spread. What is serious, though, is what this means for the spread of the pandemic.
The concept of acquisition via recombination has serious implications for the current pandemic. It was used to predict the D225G change, in part because the change was "in play" and appearing in July/August sequences at increasing frequency, even though the H1N1 sequences represented different genetic backgrounds. Similarly the clusters of Tamiflu resistance in Wales and North Carolina are also driven by recombination, as happened when the identical change was acquired in H1N1 seasonal flu in patients who were not taking Tamiflu (oseltamivir).
These changes to the swine flu virus are making it resistant to Tamiflu, the best medicine to fight this kind of viral infection.
Similarly the clusters of Tamiflu resistance in Wales and North Carolina are also driven by recombination, as happened when the identical change was acquired in H1N1 seasonal flu in patients who were not taking Tamiflu (oseltamivir).
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